听觉诱发电位指数和脑电双频指数监测舒芬太尼复合丙泊酚镇静程度的可行性研究

发布于:2021-09-17 00:04:25

浙江大学硕士毕业论文 听觉诱发电位指数及脑电双频指数监测舒芬太尼 复合丙泊酚镇静程度的可行性研究 专业 研究生 导师 麻醉学 房玲玲 周海燕 中文摘要 一、目的 通过分析从I和B工S数值的变化以及它们与患者镇静程度的相关性,探讨 AAI和BIS监测丙泊酚复合舒芬太尼镇静深度的可行性。 二、方法 选择择期在全麻下行腹部或下肢手术病人60例,年龄18~45岁,ASA I~ II级,体重指数在18.5~24.9之间,随机分为三组;单纯丙泊酚组(P组)、舒 芬太尼效应室靶浓度(Ce)0.15ng/m1复合丙泊酚组(SPl组)以及舒芬太尼(Ce) 0.30ng/ml复合丙泊酚组(SP2组),每组20例。SPl组和SP2组分别以效应室 浓度(Ce)0.15ng/m1和0.30ng/m1 TCI舒芬太尼,输注5min时开始输注丙泊 酚,初始血浆靶浓度(Cp)均为1.0 u g/ml。P组病人不用舒芬太尼。3组病人 u 丙泊酚血浆浓度(Cp)每3min递增0.2 g/ml,直至警觉/清醒评分(0AA/S) 达到1分为止。记录病人入室*卧10min(基础值)、每次调整丙泊酚Cp前即刻 AAI、BIS、Sp0:、丙泊酚Ce,并记录当时的OAA/S评分。SPSS 10.0统计软件分 浙江大学硕士毕业论文 析比较从I及B工s数值,并分析它们与0AA/S评分之间的相关性。 三、结果 1.三组病人一般资料以及基础值差异均无统计学意义。(P>0.05) 2.三组病人达相同镇静深度时丙泊酚效应室浓度有统计学差异。(P<O.05) 3.三组AAI值与OAA/S评分间相关程度的差异无统计学意义;从I数值组 间比较也无统计学差异。(P>O。05) 4.三组BIS值与OAA/S评分间的相关程度逐渐降低,分别为0.953,0.797, 0.471。(P<0.05) 5.在病人对呼唤反应消失时(OAA/S评分2分或1分),BIS值较前一组逐 渐升高。(P<O.05) 四、结论 AAI不仅可用于监测丙泊酚的镇静深度,而且能够监测丙泊酚一舒芬太尼的 协同镇静深度;而BIS仅能监测丙泊酚的镇静作用。 [关键词] 诱发电位,听觉;脑电双频指数;舒芬太尼;清醒镇静 2 浙江大学硕士毕业论文 Feasibility of auditory evoked potential index and bispectral index monitoring the depth of sedation induced by sufentanil and propof01 Postgraduate Tutor Fang ling一1ing Zhou hai—yan Abstract objectiVe To examine the feasibil时of using audito巧eVoked potential indeX and bispectml index to measure the depth of sedation induced by suf.entaIlil and propofo 1. Methods Six够ASA I or II adult patients unde塔oing electiVe abdominal surgery or lower 1imb oIrthopedic su玛e巧under general anesthesia were included in tIlis study.They 、Ⅳere raIldomly diVided into O.1 3伊oups(n=20):propofol group(P group);propofol aIld sufent蕊l 5n∥ml铲oup(SP l group);propofol趾d AAI、BIS and Sp02、vere sufeⅡ蜥l O.30n∥ml伊oup before (SP2 group).Baseline measured a11d reCorded induction of anesthesia.The iIlitialtarget plasma concentration of propofol waS set at 1.0p∥ml 1.The aIld and waS increased by O.2p∥ml every 3 mimIces umil OA削S score reached e脆ct-site concen姒ion(Ce)of propofol,AAI alld scores BIS values wIere moIlitored recorded for difI’erent OA A/S and their correlation with the sedation the interaCtion bet、^,een induced by propofol a11d sufent锄il was analyzed.Whether 3 浙江大学硕士毕业论文 su蠡:ntallil and propofol Statistical assessmem for could be reflected by BIS or AAI、)l,as analyzed too. bet、№en-group di舵rences was calculated using SPSS 1 0.O. Results 1.There、Vere a11d 110 significant difI’erences be铆een groups in patients’baSelines characteristics.(P>0.05) 2.There、耽re significam di船rences betwee

相关推荐

最新更新

猜你喜欢